These experts measured various health parameters in mice and found that at age 2 (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts. To learn how taurine impacted health, Yadav brought in other aging researchers who investigated the effect of taurine supplementation on the health and lifespan in several species. Taurine supplements in middle age improve health in old age For the mice, that meant three to four extra months, equivalent to about seven or eight human years.
At the end of the experiment, Yadav and his team found that taurine increased average lifespan by 12% in female mice and 10% in males.
Every day, the researcher fed half of them a bolus of taurine or a control solution. The researchers started with close to 250 14-month-old female and male mice (about 45 years old in people terms).
Best taurine driver#
“That’s when we started to ask if taurine deficiency is a driver of the aging process, and we set up a large experiment with mice,” Yadav says. In people, taurine levels in 60-year-old individuals were only about one-third of those found in 5-year-olds. Taurine declines with age, supplementation increases lifespan in miceįirst, Yadav’s team looked at levels of taurine in the bloodstream of mice, monkeys, and people and found that the taurine abundance decreases substantially with age. “We realized that if taurine is regulating all these processes that decline with age, maybe taurine levels in the bloodstream affect overall health and lifespan,” Yadav says. Around the same time, other researchers were finding that taurine levels correlated with immune function, obesity, and nervous system functions. Taurine first came into Yadav’s view during his previous research into osteoporosis that uncovered taurine’s role in building bone. If a molecule is a driver of aging, then restoring its youthful levels would delay aging and increase healthspan, the years we spend in good health. Less certain is whether these molecules actively direct the aging process or are just passengers going along for the ride. Many studies have found that various molecules carried through the bloodstream are associated with aging. Over the past two decades, efforts to identify interventions that improve health in old age have intensified as people are living longer and scientists have learned that the aging process can be manipulated. “This study suggests that taurine could be an elixir of life within us that helps us live longer and healthier lives.” Anti-aging molecules within us “For the last 25 years, scientists have been trying to find factors that not only let us live longer, but also increase healthspan, the time we remain healthy in our old age,” says the study’s leader, Vijay Yadav, PhD, assistant professor of genetics & development at Columbia University Vagelos College of Physicians and Surgeons.
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